SAPHO syndrome with acne fulminans and severe polyosteitis involving axial skeleton

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SAPHO syndrome with acne fulminans and severe polyosteitis involving axial skeleton

SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis), a rare inflammatory disorder, is an association of distinct skin disorders with pustules with osteoarticular inflammation. Its etiology remains unclear, and various treatment regimens frequently fail to control the disease. An 18-year-old male patient presented to the outpatient department with severe nodulocystic acne on the...

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Acne fulminans*

Acne fulminans is a rare and severe variant of acne. In Brazilian medical journals, cases are infrequently reported, confirming its rarity. We followed five young male patients with this severe variant of cutaneous lesions, accompanied by also severe systemic symptoms: fever, anorexia, weight loss, and arthralgia. All had a good response to corticosteroids (prednisone), but had significant scar...

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SAPHO Syndrome

In 1987, Chamot et al attempted to unify the various descriptions of osteoarticular disease associated with skin manifestations into a syndrome with the acronym SAPHO: synovitis, acne, pustulosis, hyperostosis, and osteitis (Chamot et al., 1987). Furthermore, the clinical feature of aseptic chronic recurrent multiple osteomyelitis (CRMO) accompanied by pustulosis with its typical presentation i...

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Testosterone-induced acne fulminans in twins with Kallmann's syndrome

INTRODUCTION Acne fulminans is a rare and severe form of acne characterized by the development of painful and inflammatory nodules on the face, chest, and back. Systemic signs are associated with the onset, including fever, chills, and musculoskeletal pain. Erythema nodosum, liver or spleen enlargement, myositis, or aseptic bone involvement have been reported more rarely. Its etiology remains u...

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SAPHO Syndrome: Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis

A 68-year-old woman with a history of breast cancer, who had undergone left quadrantectomy 24 years prior, had suffered from palmoplantar pustulosis (PPP) and pain in multiple joints and bones for 3 years. Technetium bone scanning showed increased uptake in the sternum, sternocostoclavicular joint, cervical vertebrae, lumbar vertebrae, and right knee (Picture 1, left). A radiograph of the lumba...

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ژورنال

عنوان ژورنال: Indian Dermatology Online Journal

سال: 2016

ISSN: 2229-5178

DOI: 10.4103/2229-5178.190495